Trefoil peptides
نویسندگان
چکیده
منابع مشابه
Molecular aspects of restitution: functions of trefoil peptides.
Healing of mucosal damage takes place in two phases: restitution of mucosal integrity and remodeling towards recreating the original glandular arrangements. These processes can be observed in several experimental rodent models: e.g., cryoprobe or NSAID-generated ulcers in the gastric or duodenal mucosa and following surgical resection of the small or large bowel. In some studies, it has been po...
متن کاملTrefoil Surgery
This is an expository account of a theorem of Louise Moser that describes the types of manifolds that can be constructed via Dehn surgery along a trefoil in the 3-sphere. These include lens spaces, connected sums of two lens spaces, and certain Seifert fibered spaces with three exceptional fibers. Various concepts from the topological theory of three dimensional manifolds are developed as needed.
متن کاملTrefoil factor family peptides enhance cell migration by increasing cellular osmotic permeability and aquaporin 3 levels.
Trefoil factor family (TFF) peptides are produced rapidly at sites of injury, stimulating epithelial migration, a process involving rapid changes in cell shape and volume, requiring rapid flow of water into and out of the cell. We examined the effect of TFFs on fluidity of cells by measuring their sensitivity to osmotic challenges and cell migration, and determined whether those results were me...
متن کاملcDNA cloning of rat pS2 peptide and expression of trefoil peptides in acetic acid-induced colitis.
By using a combination of the methods of reverse transcription-PCR and rapid amplification of cDNA ends, a cDNA for rat pS2 peptide (rpS2) was successfully cloned and sequenced from rat stomach. By RNA blot analysis, the gene was shown to be expressed abundantly in the stomach and only faintly in the duodenum, but not in other tissues including the distal small and large intestines. rpS2 expres...
متن کاملEffects of growth factors and trefoil peptides on migration and replication in primary oxyntic cultures.
Restitution, the lateral migration of cells over an intact basement membrane, maintains mucosal integrity. We studied the regulation of migration and proliferation of enzyme-dispersed canine oxyntic mucosa cells in primary culture. Confluent monolayers were wounded and cultured in serum-free medium, and cells migrating into the wound were counted. [3H]thymidine incorporation into DNA was studie...
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ژورنال
عنوان ژورنال: Gut
سال: 1999
ISSN: 0017-5749,1468-3288
DOI: 10.1136/gut.44.6.890